Holbrooke, 69, fell ill at the State Department on Friday and was admitted to nearby George Washington University Hospital for treatment for this life-threatening condition.
Holbrooke underwent another procedure on Sunday to improve his circulation and remains in critical condition, State Department spokesman P.J. Crowley said in a statement.
"Today, Ambassador Holbrooke underwent an additional procedure to improve circulation following yesterday's surgery," the statement said. "His family is grateful for the outpouring of support and prayers coming in from his many friends, colleagues and leaders around the world."
Richard Holbrooke In Critical Condition
Holbrooke's wife, Kati Marton, received calls from Pakistani President Asif Ali Zardari and Afghan President Hamid Karzai. Secretary of State Hillary Clinton also spoke with Karzai, the State Department said.
White House adviser David Axelrod told the CNN program "State of the Union" that Holbrooke is a "very tough person."
"He had a tremendously difficult situation Friday. He had an aortic bleed, and many people would have succumbed to that. Richard is fighting through it. Anyone who knows him -- and I was with him Friday morning before this happened -- knows how tough and resilient he is. And we're all praying that that quality sees him through now."
Holbrooke brokered the 1995 accord that ended the Balkans war and is now a key player in Obama's efforts to turn around the nine-year-old war in Afghanistan.
Richard Holbrooke In Critical Condition
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